apalutamide will lower the extent or impact of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP2C19 inducer, with medicine which have been CYP2C19 substrates may result in decreased publicity to these prescription drugs.Adjunct use, if apprehension, anxiety or ac